全文获取类型
收费全文 | 468篇 |
免费 | 62篇 |
出版年
2021年 | 6篇 |
2018年 | 8篇 |
2016年 | 9篇 |
2015年 | 16篇 |
2014年 | 9篇 |
2013年 | 18篇 |
2012年 | 19篇 |
2011年 | 24篇 |
2010年 | 15篇 |
2009年 | 15篇 |
2008年 | 22篇 |
2007年 | 10篇 |
2006年 | 13篇 |
2005年 | 14篇 |
2004年 | 14篇 |
2003年 | 17篇 |
2002年 | 10篇 |
2001年 | 18篇 |
2000年 | 14篇 |
1999年 | 9篇 |
1998年 | 6篇 |
1997年 | 7篇 |
1996年 | 3篇 |
1995年 | 4篇 |
1994年 | 11篇 |
1993年 | 5篇 |
1992年 | 16篇 |
1991年 | 11篇 |
1990年 | 12篇 |
1989年 | 8篇 |
1988年 | 11篇 |
1987年 | 5篇 |
1986年 | 5篇 |
1985年 | 6篇 |
1984年 | 8篇 |
1983年 | 5篇 |
1979年 | 6篇 |
1978年 | 4篇 |
1977年 | 8篇 |
1976年 | 6篇 |
1975年 | 10篇 |
1973年 | 7篇 |
1972年 | 4篇 |
1971年 | 3篇 |
1970年 | 5篇 |
1968年 | 5篇 |
1967年 | 10篇 |
1966年 | 5篇 |
1964年 | 5篇 |
1937年 | 3篇 |
排序方式: 共有530条查询结果,搜索用时 15 毫秒
71.
72.
73.
MOTIVATION: High-throughput 'ChIP-chip' and 'ChIP-seq' methodologies generate sufficiently large data sets that analysis poses significant informatics challenges, particularly for research groups with modest computational support. To address this challenge, we devised a software platform for storing, analyzing and visualizing high resolution genome-wide binding data. GeneTrack automates several steps of a typical data processing pipeline, including smoothing and peak detection, and facilitates dissemination of the results via the web. Our software is freely available via the Google Project Hosting environment at http://genetrack.googlecode.com 相似文献
74.
75.
Genomewide association study for susceptibility genes contributing to familial Parkinson disease 总被引:1,自引:0,他引:1
Pankratz N Wilk JB Latourelle JC DeStefano AL Halter C Pugh EW Doheny KF Gusella JF Nichols WC Foroud T Myers RH;PSG-PROGENI GenePD Investigators Coordinators Molecular Genetic Laboratories 《Human genetics》2009,124(6):593-605
Five genes have been identified that contribute to Mendelian forms of Parkinson disease (PD); however, mutations have been
found in fewer than 5% of patients, suggesting that additional genes contribute to disease risk. Unlike previous studies that
focused primarily on sporadic PD, we have performed the first genomewide association study (GWAS) in familial PD. Genotyping
was performed with the Illumina HumanCNV370Duo array in 857 familial PD cases and 867 controls. A logistic model was employed
to test for association under additive and recessive modes of inheritance after adjusting for gender and age. No result met
genomewide significance based on a conservative Bonferroni correction. The strongest association result was with SNPs in the
GAK/DGKQ region on chromosome 4 (additive model: p = 3.4 × 10−6; OR = 1.69). Consistent evidence of association was also observed to the chromosomal regions containing SNCA (additive model: p = 5.5 × 10−5; OR = 1.35) and MAPT (recessive model: p = 2.0 × 10−5; OR = 0.56). Both of these genes have been implicated previously in PD susceptibility; however, neither was identified in
previous GWAS studies of PD. Meta-analysis was performed using data from a previous case–control GWAS, and yielded improved
p values for several regions, including GAK/DGKQ (additive model: p = 2.5 × 10−7) and the MAPT region (recessive model: p = 9.8 × 10−6; additive model: p = 4.8 × 10−5). These data suggest the identification of new susceptibility alleles for PD in the GAK/DGKQ region, and also provide further support for the role of SNCA and MAPT in PD susceptibility.
Electronic supplementary material The online version of this article (doi:) contains supplementary material, which is available to authorized users.
N. Pankratz and J. B. Wilk are joint first authors. 相似文献
76.
Renato M Salgado Luciane P Capelo Rodolfo R Favaro Jocelyn D Glazier John D Aplin Telma MT Zorn 《Reproductive biology and endocrinology : RB&E》2009,7(1):60
Background
Remodeling of the extracellular matrix is one of the most striking features observed in the uterus during the estrous cycle and after hormone replacement. Versican (VER) is a hyaluronan-binding proteoglycan that undergoes RNA alternative splicing, generating four distinct isoforms. This study analyzed the synthesis and distribution of VER in mouse uterine tissues during the estrous cycle, in ovariectomized (OVX) animals and after 17beta-estradiol (E2) and medroxyprogesterone (MPA) treatments, either alone or in combination. 相似文献77.
78.
79.
Randall?S.?MorinEmail author Andrew?M.?Liebhold Scott?A.?Pugh Susan?J.?Crocker 《Biological invasions》2017,19(2):703-711
Native to Asia, the emerald ash borer (Agrilus planipennis Fairmaire) has caused extensive mortality of ash tree species (Fraxinus spp.) in the eastern United States. As of 2013, the pest was documented in 18 % of counties within the natural range of ash in the eastern United States. Regional forest inventory data from the U.S. Forest Service Forest Inventory and Analysis program were used to quantify trends in ash mortality rate and volume per hectare relative to the year of initial emerald ash borer detection. Results indicate that the annual ash mortality rate increases by as much as 2.7 % per year after initial detection of the pest in a county. Corresponding decreases in ash volume (as much as 1.8 m3 per hectare per year) continue for several more years until most live ash is killed. These results, while not necessarily representative of the effects on ash in urban ecosystems, document the severe impact this invading herbivore is having on forests as it expands its range in North America. 相似文献
80.
Identification of tissue‐specific transcriptional markers of caloric restriction in the mouse and their use to evaluate caloric restriction mimetics 下载免费PDF全文